Ubrogepant

About Ubrogepant

Ubrogepant blocks the receptor for calcitonin gene-related peptide (CGRP), a messenger involved in migraine pain. The label approves it for the acute treatment of migraine with or without aura in adults and states that it is not indicated for prevention. The dose is 50 mg or 100 mg, with or without food; if needed, a second dose can be taken at least 2 hours after the first, up to 200 mg in 24 hours. The safety of treating more than eight migraines in 30 days has not been established, so tell the prescriber if you need it that often.

There is no boxed warning. It must not be used with strong CYP3A4 inhibitors, or by anyone who has had a serious allergic reaction to it; allergic reactions, including trouble breathing and swelling of the face or throat, can appear minutes, hours or days after a dose. Since March 2025 the label also warns of new or worsening high blood pressure, most often within the first week of starting it, and of new or worsening Raynaud’s phenomenon (reduced blood flow to the fingers or toes): the drug is stopped if Raynaud’s symptoms appear, and stopping is considered if blood pressure rises with no other cause. Nausea and sleepiness are the most common side effects.

Many medicines change the dose. With moderate CYP3A4 inhibitors, such as verapamil, fluconazole, ciprofloxacin, cyclosporine, fluvoxamine and grapefruit juice, the first dose is 50 mg and no second dose is taken within 24 hours. With weak CYP3A4 inhibitors, or drugs that block only BCRP or P-gp such as quinidine, carvedilol, eltrombopag or curcumin, both doses are 50 mg; with weak or moderate CYP3A4 inducers both are 100 mg; strong inducers such as phenytoin, barbiturates, rifampin and St. John’s wort are avoided. Severe liver disease or severe kidney impairment limits each dose to 50 mg, and it is avoided in end-stage kidney disease. Each tablet is sealed in its own packet, sold in boxes of 10, 16 or 30.

Taking Ubrogepant

How to take it

At the start of a migraine, swallow one tablet with or without food, exactly as prescribed. If needed, a second tablet can be taken at least 2 hours later, but never more than 200 mg in 24 hours or more than your prescriber allows.

If you miss a dose

It is taken only when needed at the start of a migraine, not on a schedule, so there is no missed dose to make up.

Storage

At room temperature, 68°F to 77°F (20°C to 25°C), out of reach of children; each tablet comes sealed in its own packet.

Interactions to know about

Ketoconazole, itraconazole and clarithromycin must not be taken with it. Verapamil, fluconazole, ciprofloxacin, cyclosporine, fluvoxamine or grapefruit juice mean a 50 mg dose and no second dose within 24 hours. Phenytoin, barbiturates, rifampin and St. John’s wort make it work poorly, so it is avoided with them, and curcumin supplements, carvedilol and quinidine also lower the dose.

This summarizes the official prescribing information. Your prescriber’s and pharmacist’s instructions, and the leaflet that comes with your medicine, take priority.

Why the cash price for Ubrogepant differs from pharmacy to pharmacy

Ubrogepant has a single maker and no generic, so every quote is for the brand, and the differences come from what each pharmacy pays for it and the markup it adds; the dispensing fee is a small part of the total. Each box of 10, 16 or 30 tablets is priced as a unit, and a pharmacy that does not keep your strength or box size on hand may need to order it. The 50 mg and 100 mg tablets are separate products, and the pharmacist dispenses the strength written on the prescription.

Ways to pay less for Ubrogepant without insurance

• Ask the prescriber for the box size that matches how many attacks you treat in a month, and ask the pharmacy to quote that box.
• Ask the maker whether its savings or patient assistance program applies to someone paying cash; many savings offers require commercial insurance.
• Ask the prescriber whether a generic triptan, such as sumatriptan or rizatriptan, would suit you.
• Confirm the pharmacy has your strength in stock before the prescription is sent.
• Upload the prescription to Script Unlock so licensed pharmacies can quote their cash price. You pay the pharmacy directly.

Questions to ask your pharmacist about Ubrogepant

1. 1.Do any of my medicines, supplements or grapefruit juice change my dose?
2. 2.When can I take a second dose, and what is my limit in 24 hours?
3. 3.What should I do if my blood pressure rises or my fingers turn pale or numb?
4. 4.How many attacks a month can I treat before I should ask about prevention?

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